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KMID : 0378019840270110082
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New Medical Journal
1984 Volume.27 No. 11 p.82 ~ p.90
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Effects of aspirin upon the change of impulse discharges of muscular group Ia afferents induced- by Potassium Chloride
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Abstract
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In anesthetized cats the effects of aspirin upon the changes of impulse discharges of muscular group Ia afferents induced by Potassium Chloride were studied. The afferent activity was extracellularly recorded from single fiber of the distal stump of dorsal roots.
1) KCl, known as pain producing substance, regularly changed the impulse discharges of muscular group la afferents in spite of several times injection.
2) Aspirin, known as non-narcotic analgesics, did not change the impulse discharges of muscular group la afferents
3) In aspirin treated cats, KCl-induced changes of the impulse discharges of muscular group Ia afferents was significantly reduced or disappeared after onset time (5-25 min.), and reappeared like before injection of aspirin after recovery time (40-117 min.)
4) It was suggested that muscle spindle is a polymodal receptor or aspirin, increase the membrane potential, reduce the excitability of the muscle spindle.
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